TB-500 Peptide
TB-500 peptide therapy uses a lab-made fragment of thymosin beta-4 studied for its potential role in tissue repair and recovery, prescribed only when a licensed provider determines it is appropriate for you.
Studied for muscle and soft-tissue repair
Researched for how repair cells reach injured tissue
Explored for new blood vessel growth
Investigated for effects on inflammation
* Price reflects the semi-annual plan. Monthly plan: $199.00/month. Quarterly plan: $179.10/month.
How It Works
TB-500 peptide therapy is based on research into thymosin beta-4, a protein the body uses to help cells move, organize, and repair. TB-500 is a short, lab-made copy of the part of thymosin beta-4 that binds actin, a building block cells use to change shape and travel to injured areas. In animal and laboratory studies, this activity has been linked to new blood vessel growth and wound repair. TB-500 itself has not yet completed human trials, so your provider can help you weigh what is known.
Discovery & Testing Background
Thymosin beta-4 was first isolated from calf thymus tissue, and its full sequence was published in 1981 by Allan Goldstein's research group. Later studies traced some of its repair activity to a short region of seven amino acids, which became the basis for the lab-made fragment known as TB-500.
The full-length protein has been tested in early human trials, including a placebo-controlled safety study in healthy volunteers. TB-500 itself has not yet completed a published human trial, so most of what is known about it comes from laboratory and animal research.
What Is TB-500?
TB-500 is a lab-made peptide made of seven amino acids, with an acetyl group attached at one end. It matches a small section of thymosin beta-4, a 43-amino-acid protein found in most of the body's cells.
TB-500 is not an FDA-approved drug. It is available only as a compounded medication, prescribed by a licensed provider and prepared by a licensed 503A compounding pharmacy for an individual patient.
Key Takeaways
Based on Thymosin Beta-4
Studied for Tissue Repair
Early-Stage Evidence
Physician-Guided Access
Safety & Side Effects
TB-500 is not approved by the FDA. In October 2026, the U.S. Department of Health and Human Services issued an interim enforcement policy that sets specific quality and safety conditions for compounding TB-500 while the FDA completes its formal review. This policy is not an FDA approval.
TB-500 and thymosin beta-4 are prohibited under World Anti-Doping Agency rules, so competitive athletes subject to drug testing should not use them. Pregnant or breastfeeding individuals should also avoid TB-500. A licensed provider reviews your health history before any prescription is written, and you can reach a provider at any time with questions.
Quality & Specifications
The pharmacies AIRA works with are licensed in Texas and follow Texas State Board of Pharmacy rules for sterile compounding.
Molecular Profile
FORMULA
WEIGHT
CAS
SEQUENCE
Physical Properties
FORM
SOLUBILITY
STABILITY
STORAGE
TB-500 vs. Thymosin Beta-4
TB-500 | Thymosin Beta-4 | |
|---|---|---|
Length | 7 amino acids | 43 amino acids |
Sequence | Ac-LKKTETQ (positions 17-23 of thymosin beta-4) | Full-length protein |
Formula | C38H68N10O14 | C212H350N56O78S |
Weight | 889.0 g/mol | 4,963.4 g/mol |
CAS | Not available | 77591-33-4 |
Human research | No completed published trials | Early-phase trials, including an intravenous safety study in healthy volunteers |
Compounding status | Covered by the October 2026 HHS interim policy (acetate salt, injection) | Not covered by the HHS interim policy |
See the Science
A Randomized, Placebo-Controlled, Single and Multiple Dose Study of Intravenous Thymosin Beta4 in Healthy Volunteers2010 · Human phase 1 study (full-length parent protein)
Thymosin Beta4 Promotes Angiogenesis, Wound Healing, and Hair Follicle Development2004 · Preclinical research
Thymosin β4: A Multi-Functional Regenerative Peptide. Basic Properties and Clinical Applications2012 · Review
Why AIRA for TB-500?
AIRA connects you with licensed providers who review your health history and goals before deciding whether TB-500 is appropriate. If it is prescribed, your medication is prepared by an independent, state-licensed 503A compounding pharmacy and shipped discreetly to your door. You can message a provider at any time with questions and track your prescriptions and progress from one dashboard.
Chat with a provider 24/7
Trusted pharmacy
Manage goals in one place
Fast, discreet shipping
Explore TB-500 with a licensed provider.
Complete a short online health questionnaire. A licensed provider will review it and determine whether TB-500 is appropriate for you.
What our customers say about AIRA
Frequently asked questions
Is TB-500 FDA-approved?
TB-500 has not been approved by the U.S. Food and Drug Administration. It can only be prescribed through licensed clinicians where state law allows, and it is available only as a compounded medication prepared for an individual patient.
Has TB-500 been studied in humans?
Not yet in completed published trials. Its full-length parent protein, thymosin beta-4, has been tested in early human studies, including a placebo-controlled safety study in healthy volunteers. Most of what is known about TB-500 itself comes from laboratory and animal research.
Is TB-500 the same as thymosin beta-4?
No. TB-500 is a lab-made fragment of seven amino acids taken from thymosin beta-4, which is a 43-amino-acid protein. Research on the full protein does not automatically apply to the fragment.
What side effects have been reported with TB-500?
Information is limited because TB-500 has not completed human trials, but possible side effects include redness or discomfort at the injection site. In a safety study of the full parent protein, side effects were infrequent and mild to moderate. Use should be guided by a licensed provider who can help monitor how you respond.
Who should avoid TB-500?
Pregnant or breastfeeding individuals and competitive athletes subject to anti-doping rules should not use TB-500. People with a history of cancer or other serious medical conditions should discuss it with their provider first.
How is TB-500 administered?
AIRA's TB-500 is prescribed as a subcutaneous injection, meaning a small injection just under the skin. Your provider and your pharmacy label will explain how to use it.
Do I need a prescription for TB-500?
Yes. TB-500 is available only with a prescription from a licensed provider, written for you as an individual patient.
How does AIRA's online process work?
You complete an online health questionnaire, and a licensed provider reviews it to decide whether treatment is appropriate. If your state requires a live consultation, one is arranged before any prescription is written. If approved, an independent 503A compounding pharmacy prepares your medication and ships it to you.
How is the quality of TB-500 verified?
The active ingredient must come from an FDA-registered manufacturer and arrive with a certificate of analysis documenting its identity, purity, potency, and contaminant testing. The compounding pharmacy then prepares your medication under Texas State Board of Pharmacy sterile compounding rules.
Can TB-500 peptide therapy be combined with other treatments?
Some patients use TB-500 alongside other single-ingredient peptides, such as BPC-157, with each prescribed separately. Whether combining treatments makes sense for you is a decision for your provider, based on your health history and goals.
