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MOTS-C
MOTS-C is a mitochondrial-derived peptide that enhances cellular energy metabolism, supports weight management, and improves stress resilience.
Improves energy metabolism
Supports weight management
Increases exercise performance
Helps combat age-related metabolic slowdown
* Price reflects a 6-month treatment plan
MOTS-C regulates how cells process glucose and fatty acids, improving mitochondrial efficiency and energy balance. It activates pathways like AMPK, which increase insulin sensitivity, promote fat utilization, and optimize cellular stress responses. These combined effects contribute to better metabolic function, endurance, and overall vitality.
MOTS-C was discovered in 2015 by researchers at the USC Leonard Davis School of Gerontology, who identified it as a peptide encoded in mitochondrial DNA. Initial studies in animal models showed that MOTS-C improved insulin sensitivity, enhanced exercise capacity, and reduced obesity-related complications. Early human trials have confirmed its role in regulating metabolism and protecting against age-related metabolic decline. Research is ongoing, with particular interest in its potential for longevity and age-related disease prevention.
Reported side effects of MOTS-C are rare and typically mild, with some individuals experiencing temporary fatigue or injection site discomfort. No serious adverse events have been widely reported in early studies.
See the Science
Mitochondria-derived peptide MOTS-C: effects and mechanisms related to stress, metabolism and aging2023
MOTS-C is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis2021
MOTS-c regulates skeletal muscle function by directly binding and modulating CK2 (casein kinase 2)2023
Key Takeaways
Supports Healthy Aging
Naturally Occurring Peptide
Targets Metabolic Resilience
Clinically Focused on Long-Term Health
Frequently asked questions
MOTS-C has not been approved by the U.S. Food and Drug Administration. It can only be prescribed through licensed clinicians where state law allows.
Yes, early human trials and exercise studies show MOTS-C is well tolerated and may improve metabolic flexibility and physical performance.
MOTS-C seems to help the body adapt to metabolic stress, improve cellular energy use, and enhance fat and glucose metabolism. It’s sometimes referred to as a “mitochondrial messenger”.
Initial human data show MOTS-C is safe and well tolerated in short-term studies, with no serious side effects reported. Working with a licensed provider helps ensure proper monitoring and product quality.
Because MOTS-C influences cellular metabolism, individuals with severe metabolic, mitochondrial, or hormonal disorders should only use it under medical supervision. It should not be used during pregnancy or while nursing. Use should always be overseen by a clinician.
MOTS-C is most often given as a subcutaneous injection, typically in cycles aimed at supporting metabolism, energy, or exercise recovery.
Yes, MOTS-C pairs extremely well with other physician-guided therapies such as NAD+, BPC-157, CJC-1295 + Ipamorelin, AOD-9604, or Tesamorelin. Because MOTS-C supports mitochondrial function and metabolic efficiency, it complements treatments that enhance cellular energy, recovery, and healthy aging. Any stack should be clinician-supervised.
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