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CJC-1295/Ipamorelin
CJC-1295 with Ipamorelin is a synergistic peptide blend that boosts natural growth hormone release, supporting fat loss, muscle recovery, and better sleep.
Boosts natural growth hormone levels
Enhances muscle growth & recovery
Improves sleep quality
Increases energy and vitality
* Price reflects a 6-month treatment plan
CJC-1295 stimulates the pituitary gland to release more growth hormone by mimicking natural growth hormone–releasing hormone (GHRH). Ipamorelin complements this by selectively triggering growth hormone pulses without significantly affecting cortisol or prolactin. Together, they amplify natural GH cycles—leading to improved metabolism, tissue repair, and overall vitality.
CJC-1295 was developed in the early 2000s as a synthetic analog of GHRH, engineered with a longer half-life for sustained activity. Ipamorelin, discovered in the 1990s, is a selective growth hormone secretagogue designed to avoid many side effects linked to earlier peptides. Preclinical and clinical studies have shown that both compounds safely elevate endogenous GH and IGF-1 levels, enhancing lean body mass, recovery, and sleep quality. Their complementary mechanisms have made them a popular combination in anti-aging and performance medicine.
Side effects are generally mild but may include temporary flushing, water retention, or injection site irritation. Some individuals may also experience fatigue or headache, though serious adverse effects are rare.
See the Science
CJC-1295 — Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults2006
CJC-1295 — Pulsatile Secretion of Growth Hormone Persists During Continuous Stimulation by CJC-12952006
Ipamorelin — Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone-Releasing Peptide, in Healthy Volunteers1999
Ipamorelin — Ipamorelin, the First Selective Growth Hormone Secretagogue1998
Key Takeaways
Synergistic Growth-Hormone Support
Enhanced Recovery & Repair
Optimized Sleep-Cycle Benefits
Body-Composition Support
Frequently asked questions
Neither CJC-1295 or Ipamorelin has been approved by the U.S. Food and Drug Administration. They can only be prescribed through licensed clinicians where state law allows.
Yes, some small human trials have tested CJC-1295 in healthy adults; Ipamorelin has also been tested for growth hormone release.
The combo is designed to stimulate natural growth hormone (GH) release. CJC-1295 gives a sustained GH signal and Ipamorelin adds a pulse component. Together, they may raise GH and IGF-1 levels in the blood.
In tested doses, short-term use in healthy adults has been fairly tolerated, with mild side effects like injection-site reactions. Working with a licensed provider helps ensure proper monitoring and product quality.
People with cancer risk, uncontrolled diabetes, serious health conditions, or those subject to anti-doping rules should be cautious. Use should always be overseen by a clinician.
Both peptides are usually administered via subcutaneous injection, typically in the abdomen.
Many clinicians combine GH secretagogues (like this combo) with peptides for recovery, such as BPC-157 + TB-500, or fat loss, such as AOD-9604 or Tesamorelin. Any stack should be clinician-supervised.
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