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Tesamorelin
Tesamorelin is a growth hormone-releasing peptide that reduces visceral fat while supporting metabolic health and body composition.
Reduces stubborn belly fat
Improves body composition
Enhances metabolism
Supports lean muscle preservation
* Price reflects a 6-month treatment plan
Tesamorelin is a synthetic analog of growth hormone–releasing hormone (GHRH) that stimulates the pituitary gland to increase natural growth hormone production. This boost in GH elevates IGF-1 levels, enhancing fat metabolism, protein synthesis, and cellular repair. The result is a targeted reduction in abdominal fat and improvements in overall metabolic balance.
Tesamorelin was developed in the early 2000s by Theratechnologies and gained FDA approval in 2010 for the treatment of HIV-associated lipodystrophy. Clinical trials demonstrated significant reductions in visceral adipose tissue, improved lipid profiles, and favorable effects on body composition. Research has since expanded into broader metabolic applications, including obesity and age-related fat redistribution, with ongoing studies evaluating its potential beyond its original indication.
Commonly reported side effects include mild injection site reactions, joint discomfort, or fluid retention. In rare cases, increased blood sugar levels or carpal tunnel symptoms have been observed.
See the Science
Effects of Tesamorelin on Non-Alcoholic Fatty Liver Disease in HIV: A Randomised, Double-Blind, Multicentre Trial2019
Effect of Tesamorelin on Visceral Fat and Liver Fat in HIV2014
Pooled Phase-3 Analysis of Tesamorelin in ART-Treated HIV With Excess Abdominal Fat2010
Reduction in Visceral Adiposity Is Associated With Improved Metabolic Risk in Tesamorelin Phase-3 Trials2012
Long-Term Safety and Durability of Tesamorelin in HIV-Associated Abdominal Fat Accumulation2008
Key Takeaways
Targeted Visceral Fat Reduction
Metabolic Health Support
Muscle-Preserving Growth Hormone Boost
Safe & Well-Tolerated
Frequently asked questions
Tesamorelin is FDA-approved to reduce excess abdominal visceral fat in adults with HIV-associated lipodystrophy.
Yes, multiple randomized trials show meaningful VAT reduction, improved lipid profiles, and neutral overall body weight.
Tesamorelin stimulates your own GH/IGF-1 axis, which helps target deep belly fat and improve metabolic markers like triglycerides without acting as a stimulant or appetite suppressant.
Tesamorelin is generally well tolerated in studies. The most common effects are injection-site reactions, fluid retention/edema, joint aches, and transient changes in glucose/IGF-1.
People who are pregnant or nursing, have active cancer, pituitary tumors/disorders, uncontrolled diabetes, or a known hypersensitivity to Tesamorelin should not use it. Use should always be overseen by a clinician.
A once-daily subcutaneous injection, usually in the abdomen, with sites rotated. Providers monitor IGF-1 and glucose to keep therapy on target.
Yes, Tesamorelin is often paired with complementary peptides to support body-composition goals. It is commonly combined with CJC-1295 + Ipamorelin for enhanced growth-hormone signaling, AOD-9604 for additional fat-metabolism support, and MOTS-C or NAD+ for improved energy utilization and metabolic efficiency. Some patients also stack Tesamorelin with BPC-157 or BPC-157 + TB-500 when recovery or soft-tissue repair is a priority. Any stack should be clinician-supervised.
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